Fri Dec 16 2022

7 articles - From Friday Dec 09 2022 to Friday Dec 16 2022

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Lancet

Bimekizumab in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor-a inhibitors: a randomised, double-blind, placebo-controlled, phase 3 trial (BE COMPLETE).

The safety profile of bimekizumab was consistent with previous phase 3 studies in patients with plaque psoriasis, and studies of IL-17A inhibitors. UCB Pharma.

Pubmed   Journal   ReadQx 

Bimekizumab in patients with psoriatic arthritis, naive to biologic treatment: a randomised, double-blind, placebo-controlled, phase 3 trial (BE OPTIMAL).

The safety profile of bimekizumab, including the occurrence of fungal infections, was consistent with previous phase 3 studies in patients with plaque psoriasis, and with IL-17A inhibitors. Funding UCB Pharma.

Pubmed   Journal   ReadQx 

Evaluation of the safety, immunogenicity, and faecal shedding of novel oral polio vaccine type 2 in healthy newborn infants in Bangladesh: a randomised, controlled, phase 2 clinical trial.

nOPV2 was well tolerated and immunogenic in newborn infants, with two doses, at birth and 4 weeks, resulting in almost 99% of infants having protective neutralising antibodies. Bill & Melinda Gates Foundation.

Pubmed   Journal   ReadQx 

Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: updated results from DESTINY-Breast03, a randomised, open-label, phase 3 trial.

A manageable safety profile of trastuzumab deruxtecan was confirmed with longer treatment duration. Daiichi Sankyo and AstraZeneca.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Lancet

A second-generation antibody-drug conjugate to treat HER2-positive breast cancer.

Pubmed   Journal   ReadQx 

Bimekizumab in psoriatic arthritis: a great leap forward?

Pubmed   Journal   ReadQx 

Maximising the lessons learned from trial data after emergency use listing of a novel oral polio vaccine.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies